Infection Testing
Comprehensive Lyme & Co-Infection Test
Also known as: Urinary Borrelia antigen + Babesia, Bartonella & Borrelia digital PCR + Bartonella IgG
Also searched as: comprehensive Lyme test · Lyme co-infection panel
The most complete tick-borne option — direct detection in urine and blood, plus Bartonella antibodies.
Brings every tick-borne method together: the Lyme urine antigen test, digital PCR for Babesia, Bartonella, and Borrelia DNA in blood, and Bartonella antibodies in serum. Best for complex, long-standing symptoms with a history of tick or animal exposure. You may also see it called "comprehensive Lyme test" or "Lyme co-infection panel".
What the Comprehensive Lyme & Co-Infection Test measures
Lyme (urine, direct)
- OspA antigenA direct marker of Borrelia; it does not identify the exact species.
Direct DNA (blood)
- Babesia speciesA red-blood-cell parasite often found alongside Lyme.
- Bartonella speciesIncluding culture-enhanced Bartonella detection.
- Borrelia speciesThe bacteria behind Lyme disease.
Bartonella Antibodies (serum)
- B. henselaeAssociated with cat scratches and bites.
- B. quintanaHistorically spread by lice.
- B. vinsonii berkhoffiiAssociated with dogs and other animals.
- B. koehleraeAssociated with cats and fleas.
Versions available
One blood draw, one urine, one serum.
Three blood draws every other day within 5–8 days, one urine, one serum.
The right version is chosen with you based on your symptoms and history.
Who the Comprehensive Lyme & Co-Infection Test is for
Best for complex, long-standing symptoms with a history of tick or animal exposure — when you want every detection method at once.
- Known tick bite or bull's-eye rash
- Flu-like symptoms after time in a tick-prone area
- Migrating joint or muscle pain
- Chronic fatigue
- Brain fog
- Night sweats
- Nerve pain or tingling
- Ongoing illness that isn't improving
- Exposure to ticks, fleas, lice, or companion animals
Two ways to get the Comprehensive Lyme & Co-Infection Test
Request This Lab
Ordered through a licensed medical provider. Program members get help choosing the right test and reviewing results alongside their provider.
- At-home or in-office collection, depending on the test
- Our team helps you order and set up your kit
- Add Tiffeny Parker as your practitioner so I can see your results
Personalized with Tiffeny
RecommendedWant your results personally reviewed?
- One-on-one interpretation of your results
- Written Root Cause Report
- Personalized 12-week protocol
✦ Program members: practitioner discount applied. See member perks →
Labs are processed by a CLIA-certified laboratory partner. To protect your privacy, I can only see your results if you add Tiffeny Parker as your practitioner. Lab order links are affiliate links; I may earn a commission at no extra cost to you.
What results can reveal
- Direct evidence of Borrelia in urine
- DNA of Babesia, Bartonella, or Borrelia in blood
- Your immune response to four Bartonella species
How we interpret it
We read every panel through a functional lens — optimal reference ranges, ratios, and cross-panel patterns. Results become part of your written Root Cause Report and your personalized 12-week protocol.
Results are reviewed with your licensed medical provider. Alongside their care, we support your minerals, nutrition, and resilience.
Often paired with
Mold Toxicity Test
Urine testing for the toxins released by indoor molds.
Lyme & Tick-Borne Infection Test
Lyme, Babesia, and Bartonella testing explained — and how to choose between the options.
Tick-Borne DNA + Bartonella Antibody Test
Direct DNA detection for three tick-borne organisms plus Bartonella antibodies.
Often used alongside this lab
Ready-made options people often use while working on these results. Program members get a personalized plan, with a practitioner discount applied.
Common questions
Not sure which panels you need?
Start with the Root-Cause Fit Assessment. Takes about 3–5 minutes. If it looks like we're a good fit, you'll be invited to schedule a 45-minute consultation to discuss your health history, goals, and whether this program is the right next step for you.
Educational information only. Functional lab testing is not intended to diagnose, treat, cure, or prevent any disease. Results are reviewed in the context of your full health history.